Pharmaceutical Chemical Anti-Paining CAS 721-50-6 Prilocaine
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|Categories:||Active Pharmaceutical Ingredients|
|Description:||White or almost white powder|
|Solubility:||Very soluble in alcohol and in xx; slightly soluble in water.|
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Prilocaine is an aminoamide local anesthetic.
Objectives: Other Prilocaine is an aminoamide local anesthetic first prepared by Claes Tegner and Nils Lfgren. In its injectable form (trade name Citanest) it is often used in dentistry. It is also often combined with lidocaine as a preparation for skin anesthesia for conditions such as paresthesias. It is commonly used in intravenous regional anesthesia (IVRA) due to its low cardiotoxicity. In some patients, metabolites of prilocaine may cause abnormal side effects of methemoglobinemia, which can be treated with methylene blue. Maximum dose for dental use: 8.0 mg/kg (2.7 mg/lb) with a maximum dose of 500 mg.
A local anesthetic co-crystal mixture (EMLA) containing 5% lidocaine and prilocaine in a cream was found to provide effective local analgesia in normal and diseased skin, making it useful for superficial surgery and various other clinical procedure. To be effective, an adequate amount must be applied under occlusion and at the correct time before intervention.
|Items||Standard||Results of analysis|
|Appearance||White powder||white powder|
|Solubility||Almost insoluble in water, soluble in dimethyl sulfoxide, slightly soluble in solvent||Conforms|
|Ordinary impurities(Do not calculate isomer A+C)||Single impurity≤0.15%||0.03%|
|Loss on drying||≤0.5%||0.31%|
|Residue on ignition||≤0.1%||Conforms|
|Conclusion :The test results conform with USP36.|
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